Osmosis 5-Amino-1MQ
5-Amino-1MQ is a potent candidate for weight management, addressing the challenge of excess weight and obesity that often resist traditional weight loss methods due to altered metabolism. This metabolic shift hinders the breakdown of stored fats into energy, making weight loss difficult. Understanding the role of the enzyme NNMT is crucial in this context.
NNMT & Weight Gain
As fat cells expand, they produce more NNMT, a critical enzyme that slows down fat metabolism. This slowdown makes it challenging for fat cells to burn accumulated fat, leading to weight gain and contributing to chronic diseases like type 2 diabetes and cardiovascular issues.
A groundbreaking discovery by researchers at the University of Texas identified a molecule that counteracts NNMT's metabolic slowdown in white fat cells. Blocking NNMT's effects boosted fat cell metabolism and reduced the size of white fat deposits, addressing a root cause of obesity and related diseases.
NNMT: The Cellular Culprit
Nicotinamide N-methyltransferase (NNMT) plays a pivotal role in cellular energy balance. It regulates molecules within pathways governing cellular energy. When NNMT is overactive, it initiates a chain reaction: increased NNMT leads to poor fat cell metabolism, which then results in expanded fat cell mass and weight gain.
Reversing the Domino Effect: NNMT and Weight Loss
Reducing NNMT yields multiple benefits for weight loss. Firstly, decreased NNMT curbs fat cell growth. Secondly, it corrects fat cell metabolism. Thirdly, it leads to weight loss as fat cells shrink.
Blocking Metabolic Slowdown for Weight Loss
To inhibit NNMT and trigger weight loss, researchers experimented with variations of methylquinolinium (MQ). Among all the MQ variations studied, 5-amino-1MQ emerged as the most effective. This small, selective molecule penetrates cell membranes and blocks the NNMT enzyme. Importantly, it does not affect the activity of other enzymes in metabolic cycles, reducing the risk of potential side effects. This breakthrough shows promise in addressing obesity and related conditions, and managing various diseases linked to NNMT.
Benefits of 5-Amino 1MQ
- Can reverse diet-induced obesity
- Can treat related metabolic conditions
- Can increase cellular energy regulators
- Can prevent fat accumulation
- Can increase NAD+ and SAM concentrations in fat cells
- Can regulate energy expenditure in fat cells
Understanding NNMT's role in the body's complex mechanisms sheds light on new avenues for combating obesity and related health challenges. This product is for research only.
60 Capsules // 50mg per Capsule
References
Neelakantan H, Vance V, Wetzel MD, Wang H-YL, McHardy SF, Finnerty CC, et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochemical Pharmacology. 2018;147(Supplement C):141-52.
Pissios P. Nicotinamide N-Methyltransferase: More Than a Vitamin B3 Clearance Enzyme. Trends in Endocrinology & Metabolism. 2017;28(5):340-53.
Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, Pirinen E, Pulinilkunnil TC, Gong F, Wang YC, Cen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BB. NicotinamideN-methyltransferase knockdown protects against diet-induced obesity. Nature. 508(7495):258–262, APRIL 10TH, 2014
Neelakantan H, Vance V, Wang HY, McHardy SF, Watowich SJ. Non-coupled fluorescent assay for direct real-time monitoring of nicotinamide N-methyltransferase activity. Biochem. 56, 824, 2017.
Neelakantan H, Wang HY, Vance V, Hommel JD, McHardy SF, Watowich SJ. Structure–activity relationship for small molecule inhibitors of nicotinamide N- methyltransferase. J. Med. Chem. 60, 5015, 2017.
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These products are not for use in preventing, curing, or treating a particular disease or ailments. For research only, not for human consumption.